Publications

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells. Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J. Cancer Cell. 2013 May 14. doi:pii: S1535-6108(13)00177-3. 10.1016/j.ccr.2013.04.008. [Epub ahead of print] PMID:23684459

Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.  Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN , Bao S. Cell. 2013 Mar 28;153(1):139-52. doi: 10.1016/j.cell.2013.02.021. PMID: 23540695

β-Catenin/POU5F1/SOX2 Transcription Factor Complex Mediates IGF-I Receptor Signaling and Predicts Poor Prognosis in Lung Adenocarcinoma.  Xu C, Xie D, Yu SC, Yang XJ, He LR, Yang J, Ping YF, Wang B, Yang L, Xu SL, Cui W, Wang QL, Fu WJ, Liu Q, Qian C, Cui YH,Rich JN, Kung HF, Zhang X, Bian XW. Cancer Res. 2013 May 15;73(10):3181-9. doi: 10.1158/0008-5472.CAN-12-4403. Epub 2013 Mar 28.PMID: 23539445

Growth factor receptors define cancer hierarchies.   Venere M, Lathia JD, Rich JN. Cancer Cell. 2013 Feb 11;23(2):135-7. doi: 10.1016/j.ccr.2013.01.020. PMID:23410969 Mitotic control of cancer stem cells.

Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines.Sukhdeo K, Paramban RI, Vidal JG, Elia J, Martin J, Rivera M, Carrasco DR, Jarrar A, Kalady MF, Carson CT, Balderas R, Hjelmeland AB, Lathia JD, Rich JN. PLoS One. 2013;8(1):e53015. doi: 10.1371/journal.pone.0053015. Epub 2013 Jan 7. PMID:23308131

Laminin alpha 2 enables glioblastoma stem cell growth.  Lathia JD, Li M, Hall PE, Gallagher J, Hale JS, Wu Q, Venere M, Levy E, Rani MR, Huang P, Bae E, Selfridge J, Cheng L, Guvenc H, McLendon RE, Nakano I, Sloan AE, Phillips HS, Lai A, Gladson CL, Bredel M, Bao S, Hjelmeland AB, Rich JN.Ann Neurol. 2012 Nov;72(5):766-78. doi: 10.1002/ana.23674. PMID: 23280793
 

Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, Hjelmeland AB, Huang AY, Rich JN. PLoS One. 2011;6(9):e24807. Epub 2011 Sep 22. PMID: 21961046 [PDF]

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Lathia JD, Hitomi M, Gallagher J, Gadani SP, Adkins J, Vasanji A, Liu L, Eyler CE, Heddleston JM, Wu Q, Minhas S, Soeda A, Hoeppner DJ, Ravin R, McKay RD, McLendon RE, Corbeil D, Chenn A, Hjelmeland AB, Park DM, Rich JN.Cell Death Dis. 2011 Sep 1;2:e200. doi: 10.1038/cddis.2011.80. PMID: 21881602 [PDF]

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Heddleston JM, Wu Q, Rivera M, Minhas S, Lathia JD, Sloan AE, Iliopoulos O, Hjelmeland AB, Rich JN. Cell Death Differ. 2011 Aug 12. doi: 10.1038/cdd.2011.109. PMID: 21836617 [PDF]

Glioma development: where did it all go wrong? Sukhdeo K, Hambardzumyan D, Rich JN. Cell. 2011 Jul 22;146(2):187-8. PMID: 21784240 [PDF]

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Eyler CE, Wu Q, Yan K, Macswords JM, Chandler-Militello D, Misuraca KL, Lathia JD, Forrester MT, Lee J, Stamler JS, Goldman SA, Bredel M, McLendon RE, Sloan AE, Hjelmeland AB, Rich JN. Cell. 2011 Jul 8;146(1):53-66. [PDF]

Deadly teamwork: neural cancer stem cells and the tumor microenvironment.

Lathia JD, Heddleston JM, Venere M, Rich JN. Cell Stem Cell. 2011 May 6;8(5):482-5. [PDF]

Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer’s hierarchy. Venere M, Fine HA, Dirks PB, Rich JN. Glia. 2011 Aug;59(8):1148-54. doi: 10.1002/glia.21185. [PDF]

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, MacSwords J, Eyler CE, McLendon RE, Heddleston JM, Shou W, Hambardzumyan D, Lee J, Hjelmeland AB, Sloan AE, Bredel M, Stark GR, Rich JN, Bao S. Cancer Cell. 2011 Apr 12;19(4):498-511.

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, Bao S. Nat Cell Biol. 2011 Feb;13(2):142-52. Epub 2011 Jan 23.

Acidic stress promotes a glioma stem cell phenotype. Hjelmeland AB, Wu Q, Heddleston JM, Choudhary GS, MacSwords J, Lathia JD, McLendon R, Lindner D, Sloan A, Rich JN. Cell Death Differ. 2011 May;18(5):829-40. [PDF]


Molecular targeting of neural cancer stem cells: TTAGGG, you’re it! Hjelmeland AB, Rich JN. Clin Cancer Res. 2011 Jan 1;17(1):3-5. PMID: 21208901 [PDF]

Integrin alpha 6 regulates glioblastoma stem cells. Lathia JD, Gallagher J, Heddleston JM, Wang J, Eyler CE, Macswords J, Wu Q, Vasanji A, McLendon RE, Hjelmeland AB, Rich JN. Cell Stem Cell. 2010 May 7;6(5):421-32. [PDF]

Targeting A20 decreases glioma stem cell survival and tumor growth. Hjelmeland AB, Wu Q, Wickman S, Eyler C, Heddleston J, Shi Q, Lathia JD, Macswords J, Lee J, McLendon RE, Rich JN. PLoS Biol. 2010 Feb 23;8(2):e1000319. [PDF]

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth. Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, Eyler CE, Elderbroom J, Gallagher J, Schuschu J, Macswords J, Cao Y, McLendon RE, Wang XF, Hjelmeland AB, Rich JN. Stem Cells. 2009 Aug 5;27(10):2393-2404.

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN. Cancer Cell. 2009 Jun 2;15(6):501-13. [PDF]

Cancer stem cells in brain tumor biology. Rich JN, Eyler CE. Cold Spring Harb Symp Quant Biol. 2008;73:411-20. Epub 2009 Mar 27. Review.

c-Myc is required for maintenance of glioma cancer stem cells.Wang J, Wang H, Li Z, Wu Q, Lathia JD, McLendon RE, Hjelmeland AB, Rich JN.PLoS One. 2008;3(11):e3769.

Brain cancer stem cells display preferential sensitivity to Akt inhibition. Eyler CE, Foo WC, LaFiura KM, McLendon RE, Hjelmeland AB, Rich JN.Stem Cells. 2008 Dec;26(12):3027-36.

Targeting cancer stem cells through L1CAM suppresses glioma growth. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, Hjelmeland AB, Rich JN. Cancer Res. 2008 Aug 1;68(15):6043-8.

Making a tumour’s bed: glioblastoma stem cells and the vascular niche. Gilbertson RJ, Rich JN. Nat Rev Cancer. 2007 Oct;7(10):733-6. Review. [PDF]

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. [PDF]

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, Shi Q, McLendon RE, Bigner DD, Rich JN. Cancer Res. 2006 Aug 15;66(16):7843-8.

Contact Information

Address:
Lerner Research Institute
2111 E 96th Street
NE3-256
Cleveland, OH 44106

Lab: 216-636-1008
Fax: 216-636-5454

© Jeremy Rich Laboratory 2017 - Glioblastoma Stem Cells